Do I need Pre-Implantation Genetic Diagnosis (PGD)?

While PGD was first developed in 1990, its use is recently gaining widespread support due to improvements in molecular biological detection of genetic disease.  The main purpose of PGD is to help physicians select embryos unaffected by specific genetic diseases to transfer.  With assessment of embryo quality it has been a challenge to find the one embryo most likely to result in a healthy baby.  The principle parameters used to date in embryology labs are the morphology (appearance) and development of the embryo over the short time it resides in the lab.  PGD involves a biopsy of the early embryo to assess the genetic make-up of the cells removed.  This allows physicians to choose those embryos that do not have genetic abnormalities in hopes of optimizing the outcome of IVF.

Incredible improvements have been developed over the past five years that allow greater genetic assessment with better accuracy.  There are an increasing number of single-gene disorders, like cystic fibrosis or sickle cell anemia that can be diagnosed in the embryo before implantation.  By not transferring the affected embryo, the disease state can be avoided in the child.

Preimplantation Genetic Screening (PGS) embryos can be screened to detect chromosomal abnormalities (wrong number of chromosomes) that may lead to miscarriages, an abnormal fetus, or abnormal embryos which do not implant.  By choosing the embryos with normal chromosomes, the hope is to improve the chance of having a healthy baby.  However, evidence so far has not shown that miscarriage rates or delivery rates are improved, though new technology may hold promise.

Gago Center for Fertility
Brighton Office

2250 Genoa Business Park Dr.
Suite 110, Brighton, MI 48114
Phone: 810-227-3232
Fax: 810-227-3237
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Gago Center for Fertility
Lansing Office

1515 Lake Lansing Road Suite F
Lansing, MI 48912
Phone: (810)227-3232
Fax: 810-227-3237
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Gago Center for Fertility
Ann Arbor Office

1000 East Stadium Blvd. Suite 3
Ann Arbor, MI 48104
Phone: (810)227-3232
Fax: 810-227-3237
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